منابع مشابه
Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair.
It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy, suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study has revealed that a single missense mutation in cTnT...
متن کاملA global affair.
The Journal of Medical Ethics has always had a global outlook. International in its authorship, readership and editorship, the journal recognises the value of exploring how ethical issues in healthcare and scientific research manifest themselves in different geographical settings, of examining ethical issues that cross national boundaries and of ensuring that the analysis and promotion of ethic...
متن کاملA complex affair
Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrier. More recently, however, additional roles in signal transduction, differentiation and prolifera...
متن کاملA Notch Affair
(Fortini and Artavanis-Tsakonas, 1994), or that activation Poulson first described Drosophila embryos that lacked brings about proteolytic cleavage of Notch, so that an Notch function in 1937 (Poulson, 1937), referring to them intracellular portion of Notch itself moves to the nucleus as “a kind of hopeless monster.” Half a century later it and collaborates with CSL to activate transcription (K...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 2019
ISSN: 0002-0729,1468-2834
DOI: 10.1093/ageing/afz103.97